Validation of the Composite End Point of Graft-Versus-Host Disease-Free, Relapse-Free Survival
نویسندگان
چکیده
منابع مشابه
Composite end point of graft-versus-host disease-free, relapse-free survival after allogeneic hematopoietic cell transplantation.
The success of allogeneic hematopoietic cell transplantation (HCT) is typically assessed as individual complications, including graft-versus-host disease (GVHD), relapse, or death, yet no one factor can completely characterize cure without ongoing morbidity. We examined a novel composite end point of GVHD-free/relapse-free survival (GRFS) in which events include grade 3-4 acute GVHD, systemic t...
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The cure of hematologic disorders by allogeneic hematopoietic stem cell transplantation (HSCT) is often associated with major complications resulting in poor outcome, including graft-versus-host disease (GVHD), relapse, and death. A novel composite endpoint of GVHD-free/relapse-free survival (GRFS) in which events include grades 3-4 acute GVHD, chronic GVHD requiring systemic therapy, relapse, ...
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We previously reported that bone marrow grafts from matched sibling donors resulted in best graft-versus-host disease-free, relapse-free survival at 1-year post allogeneic hematopoietic cell transplantation. However, pediatric patients comprised the majority of bone marrow graft recipients in that study. To better define this outcome in adults and pediatric patients at 1- and 2-years post- allo...
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15 صفحه اولModeling relapse-free survival with time-dependent covariate graft-versus-host disease in patients with acute leukemia.
The role of graft-versus-host disease (GVHD) on relapse-free survival (RFS) is being increasingly recognised in clinical studies. In the study reported by Lee and colleagues Kaplan-Meier (KM) RFS estimates of patients stratified according to the occurrence of acute GVHD (aGVHD) have been plotted. A stratification on a variable unknown at baseline is inappropriate for calculation and graphical p...
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ژورنال
عنوان ژورنال: Biology of Blood and Marrow Transplantation
سال: 2016
ISSN: 1083-8791
DOI: 10.1016/j.bbmt.2015.11.825